Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance
نویسندگان
چکیده
منابع مشابه
Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance
Promoting remyelination is crucial for patients with demyelinating diseases including multiple sclerosis. However, it is still a circuitous conundrum finding a practical remyelinating therapy. Electroacupuncture (EA), originating from traditional Chinese medicine (TCM), has been widely used to treat CNS diseases all over the world, but the role of EA in demyelinating diseases is barely known. I...
متن کاملMicroglia: Senescence Impairs Clearance of Myelin Debris
Growing evidence highlights the crucial physiological functions of microglia that rely on their phagocytic activities, which can be compromised with age. A new study reports the impaired clearance of myelin debris by microglia in the brain, leading to insoluble lysosomal inclusions and contributing to the immune dysfunction and senescence of these cells.
متن کاملInefficient clearance of myelin debris by microglia impairs remyelinating processes
An imbalance between remyelinating and demyelinating rates underlies degenerative processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic strategy would be to stimulate remyelination while limiting demyelination. Although accumulation of myelin debris impairs remyelination, the mechanisms regulating the clearance of such debris by mononuclear phagocytic cells are ...
متن کاملRemyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice.
Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and studied demyelination/remyelination and cellular reactions in the corpus callosum and motor cortex by histology, immunohistochemistry, ...
متن کاملP 45: De- and Remyelination Affect Cognitive and Locomotor Abilities in Mice
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammatory and neurodegenerative processes. One of its pathophysiological hallmarks is demyelination, a consequence of oligodendroglial cell death leading supply shortfall and missing electrical insulation to axons. Demyelination induced consequences on neuronal network activity and subsequen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2017
ISSN: 1662-453X
DOI: 10.3389/fnins.2016.00613